Clinical bioethicist Charles E. Binkley and attorney David S. Kemp consider whether—and how—the Food and Drug Administration might reasonably regulate vaping devices, also known as electronic nicotine delivery system (ENDS), so that they can serve as an ethical alternative to combustible tobacco products. Specifically, Binkley and Kemp and call for further longitudinal data on the risks and benefits of ENDS and propose certain contingencies that must be in place before ENDS can serve as a viable replacement for conventional combustible tobacco products.